Knockdown of transglutaminase-2 prevents early age-induced vascular changes in mice
Acta cir. bras.
; 33(11): 991-999, Nov. 2018. ilus, graf
Article
em En
| VETINDEX
| ID: vti-18420
Biblioteca responsável:
BR68.1
ABSTRACT
Purpose:
To determine whether the absence of transglutaminase 2 enzyme (TG2) in TG2 knockout mice (TG2-/-) protect them against early age-related functional and histological arterial changes.Methods:
Pulse wave velocity (PWV) was measured using non-invasive Doppler and mean arterial pressure (MAP) was measured in awake mice using tail-cuff system. Thoracic aortas were excised for evaluation of endothelial dependent vasodilation (EDV) by wire myography, as well as histological analyses.Results:
PWV and MAP were similar in TG2-/-mice to age-matched wild type (WT) control mice. Old WT mice exhibited a markedly attenuated EDV as compared to young WT animals. The TG2-/-young and old mice had enhanced EDV responses (p<0.01) as compared to WT mice. There was a significant increase in TG2 crosslinks by IHC in WT old group compared to Young, with no stain in the TG2-/-animals. Optical microscopy examination of Old WT mice aorta showed thinning and fragmentation of elastic laminae. Young WT mice, old and young TG2-/-mice presented regularly arranged and parallel elastic laminae of the tunica media.Conclusion:
The genetic suppression of TG2 delays the age-induced endothelial dysfunction and histological modifications.(AU)Palavras-chave
Texto completo:
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Base de dados:
VETINDEX
Assunto principal:
Artérias
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Transglutaminases
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Fatores Etários
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Camundongos Knockout
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Fatores Relaxantes Dependentes do Endotélio
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2018
Tipo de documento:
Article
/
Project document