Análise histopatológica do epitélio uterino de ratas wistar após 30 dias de tratamento com extrato etanólico de Simarouba versicolor / Histopathology of the uterine epithelium of Wistar rats after 30 days of treatment with ethanol extract of Simarouba versicolor

ABSTRACT

Simarouba versicolor belongs to Simaroubaceae family, it has been used in folk medicine and hasextensive proven biological activity. However, histopalógicos studies in the reproductive organs are scarce. Thisstudy aimed to evaluate the effect of ethanol extract of S. versicolor (Sv-EtOH) at doses 10, 20, 40 mg / kg in theuterine epithelium after 30 days of treatment. After euthanasia, the uteri were removed, fixed in 10% bufferedformalin. Followed by dehydration with alcohol (70-100%), cleared in xylene, subjected to impregnation andinclusion in paraffin. Cut thickness of 5.0 µm and subsequently submitted to hematoxylin-eosin and examinedunder a microscope. The results showed eosinophilic inflammatory infiltrate of medium intensity reaching themuscle layer. The highest dose showed changes of the endometrium, epithelium with increased with 100%eosinophil infiltrate the lamina propria of moderately severe intensity and mucosal epithelial cell swelling.(AU)