Efeito do extrato etanólico das folhas de Myracrodruon urundeuva sobre a contratilidade uterina de ratas Wistar / Effect of ethanol extract of Myracrodruon urundeuva leaves on contractility uterine of Wistar rats

ABSTRACT

Were used 30 virgin female Wistar rats that were mated with adult male rats and vaginal smears were made to detect pregnancy. The pregnant rats were subdivided into pre-treated group with ethanol extract of M. urundeuva (EEMU) at doses of 125, 250 and 500mg/kg PO for 13 days and the untreated group that receiving distilled water being the extract at concentrations of 125, 250 and 500µg/mL added directly to the bath tub for isolated organ. Rats were euthanized by anesthetic overdose and the uterine strips were placed in the bath tub for isolated organ and subjected to contraction with 80mM KCl, oxytocin (16.8IU/mg) and Carbachol (0.3µM). Treatment with EEMU and its direct application did not interfere with uterine contractility of pregnant rats.(AU)