Cellular immune response in acute hepatitis B leading to chronic carrier state
(East. Mediterr. health j).
em Inglês
| WHO IRIS
| ID: who-117406
Biblioteca responsável:
CH1.1
ABSTRACT
Immunological studies among jaundiced patients revealed significant changes in T-helper and T-suppressor cells among chronic HBV cases from the acute and control groups. The chronic cases revealed a highly significant decrease in interleukin-2R expression but their low interferon-gamma values were statistically nonsignificant from the control group. The acute cases recorded the highest interleukin-2R and interferon-gamma values. Lymphocyte blastogenesis assay in response to different mitogens and antigens produced two groups responders [acute cases] and nonresponders [chronic cases]. The responders revealed more intact specific and nonspecific cellular immune responses. Neither group differed with regard to their proliferative response to HBsAg, but vigorous response to HBcAg was a significant feature of the responders
Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
WHO IRIS
Assunto principal:
Linfócitos T
/
Portador Sadio
/
Incidência
/
Fatores de Risco
/
Interferons
/
Interleucina-2
/
Hepatite B
/
Imunidade Celular
/
Testes de Função Hepática
Idioma:
Inglês
Revista:
East. Mediterr. health j
Ano de publicação:
1997