Comparative proteomics study on meglumine antimoniate sensitive and resistant Leishmania tropica isolated from Iranian anthroponotic cutaneous leishmaniasis patients
(East. Mediterr. health j).
em Inglês
| WHO IRIS
| ID: who-118460
Biblioteca responsável:
CH1.1
ABSTRACT
In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis [CL], we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed activated protein kinase c receptor [LACK], alpha tubulin [X2], prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates
Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Base de dados:
WHO IRIS
Assunto principal:
Compostos Organometálicos
/
Espectrometria de Massas
/
Leishmania tropica
/
Eletroforese em Gel Bidimensional
/
Leishmaniose Cutânea
/
Proteômica
/
Meglumina
Idioma:
Inglês
Revista:
East. Mediterr. health j
Ano de publicação:
2012