TNF-alpha and homocysteine levels in type 1 diabetes mellitus
(East. Mediterr. health j).
em Inglês
| WHO IRIS
| ID: who-119075
Biblioteca responsável:
CH1.1
ABSTRACT
The role of homocysteine as an independent risk factor for vascular endothelial damage, and the possible link between homocysteine and tumour necrosis factor-alpha [TNF-alpha] as two synergistic risk factors for beta-cell apoptosis in type 1 diabetes mellitus was studied. Plasma homocysteine levels were significantly elevated in all diabetic patients compared with controls and diabetic patients with vascular complications showed higher elevations. Furthermore, homocysteine levels showed significant positive correlation with the degree of microalbuminuria. TNF-alpha levels were elevated in all diabetic patients compared with controls. These results may have therapeutic implications
Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doença Cardiovascular
/
Diabetes Mellitus
/
Doenças do Sistema Endócrino
/
Desnutrição e Deficiências Nutricionais
Base de dados:
WHO IRIS
Assunto principal:
Hemoglobinas Glicadas
/
Colesterol
/
Fator de Necrose Tumoral alfa
/
Apoptose
/
Hiper-Homocisteinemia
/
Diabetes Mellitus Tipo 1
/
Angiopatias Diabéticas
/
Neuropatias Diabéticas
/
Albuminúria
/
Homocisteína
Idioma:
Inglês
Revista:
East. Mediterr. health j
Ano de publicação:
2001