Bone marrow transplantation in thalassaemia patients in Shiraz, Islamic Republic of Iran
(East. Mediterr. health j).
em En
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| ID: who-119097
Biblioteca responsável:
CH1.1
ABSTRACT
We report the results of allogeneic bone marrow transplantation in 26 female and 37 male patients with beta-thalassaemia major [age range 2-17 years], performed at Namazi Hospital over the period 1992-99. In all cases, standard conditioning and immunosuppressive regimens were employed. Currently, 50 patients remain thalassaemia-free, 9 of whom have developed chronic graft-versus-host disease. There were 8 deaths among the 13 unsuccessful transplant cases 4 due to acute uncontrollable graft-versus-host disease, and 4 to non-transplant-related causes such as hypoglycaemia, hypersensitivity reactions and advanced disease. We conclude that allogeneic bone marrow transplantation is an effective therapy for the treatment of beta-thalassaemia major, particularly for patients classified as classes I and II
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Texto completo:
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Coleções:
04-international_org
Base de dados:
WHOLIS
Assunto principal:
Prednisolona
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Pré-Escolar
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Doença Crônica
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Transplante de Medula Óssea
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Imunoglobulinas Intravenosas
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Talassemia beta
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Condicionamento Pré-Transplante
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Rejeição de Enxerto
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Hipoglicemia
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Anti-Inflamatórios
Idioma:
En
Revista:
East. Mediterr. health j
Ano de publicação:
2001