Advances in the study of the m6A methyltransferase METTL3 promoting bladder cancer progression via AFF4/NF-κB/MYC signaling network / 现代泌尿外科杂志
Journal of Modern Urology
; (12): 635-639, 2023.
Article
em Zh
| WPRIM
| ID: wpr-1006038
Biblioteca responsável:
WPRO
ABSTRACT
Bladder cancer (BCa) is one of the most common cancers in urology,whose pathogenesis is still unclear. Methyltransferase-like 3(METTL3) is the most important part of N6-methyladenosine methyltransferase complex (m6A MTC),which mediates the methylation of mRNA to regulate the stability and translation process of mRNA. Researches have shown that METTL3 can promote BCa development via AFF4/NF-κB/MYC signaling network,which involves many kinds of signaling molecules. In addition,METTL3 can affect the expressions of AFF4,NF-κB and MYC,so as to affect their downstream signaling pathways and finally promote the malignant progression of tumor.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Modern Urology
Ano de publicação:
2023
Tipo de documento:
Article