Research progress on mTOR signaling pathway and regulatory T cell nutrition metabolic regulation mechanism / 细胞与分子免疫学杂志
Chinese Journal of Cellular and Molecular Immunology
; (12): 69-73, 2024.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-1009477
Biblioteca responsável:
WPRO
ABSTRACT
In the tumor microenvironment, metabolic reprogramming can impact metabolic characteristics of T cells, thus inducing immunosuppression to promote tumor immune escape. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in regulating diverse functions of various immune cells. This review mainly focuses on the molecular mechanism of mTOR signaling in regulating cellular energy metabolism process, and the activation status of mTOR signaling under different nutritional environments. In addition, it also summarizes the role of the mTOR signaling in regulatory T cell (Tregs) metabolism and function in current studies, and evaluates the potential of mTOR as a clinical immunotherapeutic target and its current application challenges.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transdução de Sinais
/
Terapia de Imunossupressão
/
Linfócitos T Reguladores
/
Sirolimo
/
Serina-Treonina Quinases TOR
/
Reprogramação Metabólica
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Cellular and Molecular Immunology
Ano de publicação:
2024
Tipo de documento:
Artigo