Anti-hepatitis B virus activities of natural products and their antiviral mechanisms / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 803-811, 2023.
Article
em En
| WPRIM
| ID: wpr-1010992
Biblioteca responsável:
WPRO
ABSTRACT
Chronic hepatitis B (CHB) infections caused by the hepatitis B virus (HBV) continue to pose a significant global public health challenge. Currently, the approved treatments for CHB are limited to interferon and nucleos(t)ide analogs, both of which have their limitations, and achieving a complete cure remains an elusive goal. Therefore, the identification of new therapeutic targets and the development of novel antiviral strategies are of utmost importance. Natural products (NPs) constitute a class of substances known for their diverse chemical structures, wide-ranging biological activities, and low toxicity profiles. They have shown promise as potential candidates for combating various diseases, with a substantial number demonstrating anti-HBV properties. This comprehensive review focuses on the current applications of NPs in the fight against HBV and provides a summary of their antiviral mechanisms, considering their impact on the viral life cycle and host hepatocytes. By offering insights into the world of anti-HBV NPs, this review aims to furnish valuable information to support the future development of antiviral drugs.
Palavras-chave
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Antivirais
/
Produtos Biológicos
/
Vírus da Hepatite B
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Hepatite B Crônica
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Hepatócitos
Limite:
Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2023
Tipo de documento:
Article