Research progress on autocrine and paracrine regulation of osteosarcoma cell growth / 中国生物制品学杂志
Chinese Journal of Biologicals
; (12): 239-244, 2024.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-1011474
Biblioteca responsável:
WPRO
ABSTRACT
@#Osteosarcoma(OS)is one of the most common malignant tumors in bone tissue,and its specific mechanism is not yet fully clear. Studies have shown that OS cells express different cytokines(CKs)and their receptors in the development stage of tumors,and enable them to grow autonomously and confer metastatic ability through autocrine and paracrine effects. In this regard,the most important CKs mainly includes insulin-like growth factor-1,transforming growth factor-β,chemokine 5 and interleukin-8,which can regulate the tumor microenvironment that is conducive to tumor growth,invasion and metastasis. This review summarizes the role and mode of action of CKs and their biological relevance to OS cells,hoping to provide effective new markers and therapeutic targets for clinical treatment of OS.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Biologicals
Ano de publicação:
2024
Tipo de documento:
Artigo