Management of Refractory Helicobacter pylori Infection: Consensus and Controversy / 胃肠病学

ABSTRACT

The harm of Helicobacter pylori (Hp) infection has been fully recognized, and the eradication of Hp to prevent and treat Hp-associated diseases is highly cost-effective. Now, the statement "Hp infected individuals should be offered eradication therapy, unless there are competing considerations" has been widely accepted. However, the eradication rate of Hp in clinical practice is gradually decreasing, which affects negatively the prevention and control of Hp infection. The goals are unified, but difficulties are encountered in the implementation. Therefore, the treatment of "refractory Hp infection" has become a hot research spot today. In this paper, the controversy over the definition of "refractory Hp infection", the causes for "refractory" infection and related countermeasures are described in detail.