Research Progress on MicroRNAs in Helicobacter pylori-negative Gastric Cancer / 胃肠病学

ABSTRACT

Helicobacter pylori (Hp) infection is closely related to gastric cancer, and with the implementation of eradication therapy, the infection rate of Hp decreases gradually and the proportion of gastric cancer caused by Hp infection also decreases accordingly. Hence, Helicobacter pylori-negative gastric cancer (HpNGC) become a more common type of gastric cancer. It has been reported in recent years that there are some differences in pathobiological behavior between Helicobacter pylori-positive gastric cancer (HpPGC) and HpNGC, which indicates that the pathogenesis of HpNGC may be different from that of HpPGC. Relevant studies have found that the expression profile of microRNAs (miRNAs) in HpNGC is different from that in HpPGC, suggesting that the differentially expressed miRNAs may play an important role in the pathogenesis of HpNGC. This article reviewed the research progress on miRNAs in the pathogenesis, diagnosis and treatment of HpNGC, providing a new insight for exploring the pathogenesis of HpNGC.