Progress on the role of PRMTs in hematological malignancy diseases / 国际儿科学杂志

ABSTRACT

The protein arginine methyltransferases(PRMTs)family has a wide range of molecular functions and is involved in the generation, development, proliferation and differentiation of hematopoietic cells in the stem cell development.In hematological malignancy diseases, PRMTs can be involved in many important biological processes including cell proliferation, cell cycle, gene transcription, and DNA damage repair through methylation pathways.The abnormal expression of PRMTs can lead to the occurrence and development of malignancy diseases, especially in childhood leukemia.Targeted PRMTs therapy can effectively inhibit the proliferation and survival of tumor cells by reducing the expression of PRMTs.Therefore, the relationship between PRMTs and hematological malignancy diseases has received much attention and is likely to become an important target for treatment in the future.This article reviews the role and mechanism of PRMTs in hematological malignancy diseases, in order to provide new strategies for the treatment of hematological malignancy diseases.