Progress of intestinal organoids in necrotizing enterocolitis / 国际儿科学杂志

ABSTRACT

Necrotizing enterocolitis(NEC)is an acute intestinal inflammation characterized by mucosal edema, epithelial ischemic necrosis, and crypt destruction.The intestinal organoid 3D culture system derived from intestinal stem cells has been developed as a valuable research model for studying NEC in vitro.To fully understand the progression of NEC, it is crucial to comprehend the changes that take place in the intestinal stem cell niche, as well as the interactions among different cell types in the intestinal crypt.On the other hand, intestinal organoids can also be used directly for the treatment of NEC, and for screening of specific drugs or nutrients for NEC in vitro .This article provides a review of intestinal organoids and their recent advancements in NEC research.