Role of microglia lipid metabolism in Alzheimer's disease / 中华神经医学杂志
Chinese Journal of Neuromedicine
; (12): 1168-1172, 2022.
Article
em Zh
| WPRIM
| ID: wpr-1035754
Biblioteca responsável:
WPRO
ABSTRACT
Microglia (MG) are resident immune cells in the central nervous system (CNS) and the first defense line of CNS damage. The maintenance of MG function requires abundant energy, and lipid can serve as an energy source for the brain when glucose utilization is limited, and lipid can also function as signaling molecule. Alzheimer's disease (AD) is the most common neurodegenerative disease, and MG lipid metabolism plays an important role in the development of this disease. Drugs targeting lipid metabolism provide a new direction for AD treatment. This review starts with the specific mechanism of lipid metabolism in MG, and briefly introduces the effect of lipid metabolism on MG function and its role in AD.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Neuromedicine
Ano de publicação:
2022
Tipo de documento:
Article