Association between Resting Heart Rate and Inflammatory Markers (White Blood Cell Count and High-Sensitivity C-Reactive Protein) in Healthy Korean People / 가정의학회지
Korean Journal of Family Medicine
; : 8-13, 2017.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-109995
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Inflammation is an important underlying mechanism in the pathogenesis of atherosclerosis, and an elevated resting heart rate underlies the process of atherosclerotic plaque formation. We hypothesized an association between resting heart rate and subclinical inflammation.METHODS:
Resting heart rate was recorded at baseline in the KoGES-ARIRANG (Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population) cohort study, and was then divided into quartiles. Subclinical inflammation was measured by white blood cell count and high-sensitivity C-reactive protein. We used progressively adjusted regression models with terms for muscle mass, body fat proportion, and adiponectin in the fully adjusted models. We examined inflammatory markers as both continuous and categorical variables, using the clinical cut point of the highest quartile of white blood cell count (≥7,900/mm³) and ≥3 mg/dL for high-sensitivity C-reactive protein.RESULTS:
Participants had a mean age of 56.3±8.1 years and a mean resting heart rate of 71.4±10.7 beats/min; 39.1% were men. In a fully adjusted model, an increased resting heart rate was significantly associated with a higher white blood cell count and higher levels of high-sensitivity C-reactive protein in both continuous (P for trend <0.001) and categorical (P for trend <0.001) models.CONCLUSION:
An increased resting heart rate is associated with a higher level of subclinical inflammation among healthy Korean people.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Contagem de Células Sanguíneas
/
Células Sanguíneas
/
Proteína C-Reativa
/
Tecido Adiposo
/
Epidemiologia
/
Estudos de Coortes
/
Genoma
/
Aterosclerose
/
Adiponectina
/
Placa Aterosclerótica
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Family Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo