Characterization of Gp41 Polymorphisms in the Fusion Peptide Domain and T-20 (Enfuvirtide) Resistance-Associated Regions in Korean HIV-1 Isolates
Journal of Korean Medical Science
; : 456-459, 2014.
Article
em En
| WPRIM
| ID: wpr-111996
Biblioteca responsável:
WPRO
ABSTRACT
HIV-1 gp41 is an envelope protein that plays an essential role in virus entry. The mutation of gp41 affects HIV-1 entry and susceptibility to the fusion inhibitor T-20. Therefore, we analyzed the natural polymorphism of gp41 of 163 HIV-1 isolates from T-20-naive Koreans infected with HIV-1. This study of gp41 polymorphisms showed that insertions in the fourth threonine (74.8%) and L7M substitutions (85.3%) were more frequent in the fusion peptide motif in Korean HIV-1 isolates compared with those from other countries. Minor T-20 resistance mutations such as L45M (1.2%), N126K (1.2%), and E137K (6.7%) were detected, but the critical T-20 resistance mutations were not detected in the gp41 HR1 and HR2 regions. In addition, the N42S mutation (12.9%) associated with T-20 hypersusceptibility was detected at a high frequency. These results may serve as useful data for studies considering T-20 for use in the development of a more effective anti-retroviral treatment in Korea.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fragmentos de Peptídeos
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Polimorfismo Genético
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Proteína gp41 do Envelope de HIV
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Infecções por HIV
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HIV-1
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Estrutura Terciária de Proteína
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Fármacos Anti-HIV
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Farmacorresistência Viral
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Internalização do Vírus
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República da Coreia
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2014
Tipo de documento:
Article