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Clinicopathologic Analysis of Pituitary Adenoma: A Single Institute Experience
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-112005
Biblioteca responsável: WPRO
ABSTRACT
Pituitary adenoma (PA) is a common benign neuroendocrine tumor; however, the incidence and proportion of hormone-producing PAs in Korean patients remain unknown. Authors analyzed 506 surgically resected and pathologically proven pituitary lesions of the Seoul National University Hospital from 2006 to 2011. The lesions were categorized as PAs (n = 422, 83.4%), Rathke's cleft cysts (RCCs) (n = 54, 10.6%), inflammatory lesions (n = 8, 1.6%), meningiomas (n = 4), craniopharyngiomas (n = 4), granular cell tumors (n = 1), metastatic renal cell carcinomas (n = 2), germinomas (n = 1), ependymomas (n = 1), and unsatisfactory specimens (n = 9, 1.8%). PAs were slightly more prevalent in women (M F = 11.17) with a mean age of 48.8 yr (9-80 yr). Immunohistochemical analysis revealed that prolactin-producing PAs (16.6%) and growth hormone-producing adenomas (9.2%) were the most common functional PAs. Plurihormonal PAs and nonfunctioning (null cell) adenomas were found in 14.9% and 42.4% of patients with PAs, respectively. The recurrence rate of PAs was 11.1%, but nearly 0% for the remaining benign lesions such as RCCs. 25.4% of patients with PAs were treated by gamma-knife after surgery due to residual tumors or regrowth of residual tumor. In conclusion, the pituitary lesions and the proportions of hormone-producing PAs in Korean patients are similar to those of previous reports except nonfunctioning (null cell) PAs, which are unusually frequent.
Assuntos

Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Hipofisárias / Prolactina / Recidiva / Hormônio do Crescimento / Imuno-Histoquímica / Adenoma / Fatores Sexuais / Fatores Etários / Cistos do Sistema Nervoso Central Limite: Adolescente / Adulto / Idoso / Idoso, 80 anos ou mais / Criança / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2014 Tipo de documento: Artigo
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Hipofisárias / Prolactina / Recidiva / Hormônio do Crescimento / Imuno-Histoquímica / Adenoma / Fatores Sexuais / Fatores Etários / Cistos do Sistema Nervoso Central Limite: Adolescente / Adulto / Idoso / Idoso, 80 anos ou mais / Criança / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Korean Medical Science Ano de publicação: 2014 Tipo de documento: Artigo
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