Understanding Disease Susceptibility through Population Genomics
Genomics & Informatics
; : 234-238, 2012.
Article
em En
| WPRIM
| ID: wpr-11759
Biblioteca responsável:
WPRO
ABSTRACT
Genetic epidemiology studies have established that the natural variation of gene expression profiles is heritable and has genetic bases. A number of proximal and remote DNA variations, known as expression quantitative trait loci (eQTLs), that are associated with the expression phenotypes have been identified, first in Epstein-Barr virus-transformed lymphoblastoid cell lines and later expanded to other cell and tissue types. Integration of the eQTL information and the network analysis of transcription modules may lead to a better understanding of gene expression regulation. As these network modules have relevance to biological or disease pathways, these findings may be useful in predicting disease susceptibility.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fenótipo
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DNA
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Linhagem Celular
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Regulação da Expressão Gênica
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Epidemiologia Molecular
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Locos de Características Quantitativas
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Suscetibilidade a Doenças
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Metagenômica
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Transcriptoma
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Genomics & Informatics
Ano de publicação:
2012
Tipo de documento:
Article