Selective Effects of Curcumin on CdSe/ZnS Quantum-dot-induced Phototoxicity Using UVA Irradiation in Normal Human Lymphocytes and Leukemia Cells
Toxicological Research
; : 35-42, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-118066
Biblioteca responsável:
WPRO
ABSTRACT
Quantum dots (QDs) have received considerable attention due to their potential role in photosensitization during photodynamic therapy. Although QDS are attractive nanomaterials due to their novel and unique physicochemical properties, concerns about their toxicity remain. We suggest a combination strategy, CdSe/ZnS QDs together with curcumin, a natural yellow pigment from turmeric, to reduce QD-induced cytotoxicity. The aim of this study was to explore a potentially effective cancer treatment co-exposure of HL-60 cells and human normal lymphocytes to CdSe/ZnS QDs and curcumin. Cell viability, apoptosis, reactive oxygen species (ROS) generation, and DNA damage induced by QDs and/or curcumin with or without ultraviolet A (UVA) irradiation were evaluated in both HL-60 cells and normal lymphocytes. In HL-60 cells, cell death, apoptosis, ROS generation, and single/double DNA strand breaks induced by QDs were enhanced by treatment with curcumin and UVA irradiation. The protective effects of curcumin on cell viability, apoptosis, and ROS generation were observed in normal lymphocytes, but not leukemia cells. These results demonstrated that treatment with QD combined with curcumin increased cell death in HL-60 cells, which was mediated by ROS generation. However, curcumin acted as an antioxidant in cultured human normal lymphocytes.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Leucemia
/
Doenças da Pele
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fotoquimioterapia
/
Transtornos de Fotossensibilidade
/
Dano ao DNA
/
DNA
/
Linfócitos
/
Leucemia
/
Sobrevivência Celular
/
Morte Celular
/
Espécies Reativas de Oxigênio
/
Dermatite Fototóxica
Limite:
Humanos
Idioma:
Inglês
Revista:
Toxicological Research
Ano de publicação:
2013
Tipo de documento:
Artigo