Distribution and accumulation of 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice / 대한수의학회지
Korean Journal of Veterinary Research
; : 57-60, 2015.
Article
em En
| WPRIM
| ID: wpr-121221
Biblioteca responsável:
WPRO
ABSTRACT
To investigate kinetics of free 177Lu and 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of 5 microCi/mouse or 15 mg/kg body weight, respectively. Free 177Lu radioactivity levels were highest in kidney followed by liver and lung 1 day post-injection. 177Lu-labeled TCL-SPION radioactivity in liver and spleen was significantly higher compared to that of other organs throughout the experimental period (p < 0.05). Radioactivity in blood, brain, and epididymis rapidly declined until 28 days. Based on these results, TCL-SPION could be a safe carrier of therapeutics.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Radioatividade
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Baço
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Suspensões
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Veias
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Peso Corporal
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Encéfalo
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Cinética
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Epididimo
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Nanopartículas
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Ferro
Limite:
Animals
Idioma:
En
Revista:
Korean Journal of Veterinary Research
Ano de publicação:
2015
Tipo de documento:
Article