Postnatal Treadmill Exercise Alleviates Prenatal Stress-Induced Anxiety in Offspring Rats by Enhancing Cell Proliferation Through 5-Hydroxytryptamine 1A Receptor Activation / 대한배뇨장애요실금학회지
International Neurourology Journal
; : S57-S64, 2016.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-122235
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
Stress during pregnancy is a risk factor for the development of anxiety-related disorders in offspring later in life. The effects of treadmill exercise on anxiety-like behaviors and hippocampal cell proliferation were investigated using rats exposed to prenatal stress.METHODS:
Exposure of pregnant rats to a hunting dog in an enclosed room was used to induce stress. Anxiety-like behaviors of offspring were evaluated using the elevated plus maze test. Immunohistochemistry for the detection of 5-bromo-2'-deoxyuridine and doublecortin (DCX) in the hippocampal dentate gyrus and 5-hydroxytryptamine 1A receptors (5-HT(1A)) in the dorsal raphe was conducted. Brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) levels in the hippocampus were evaluated by western blot analysis.RESULTS:
Offspring of maternal rats exposed to stress during pregnancy showed anxiety-like behaviors. Offspring also showed reduced expression of BDNF, TrkB, and DCX in the dentate gyrus, decreased cell proliferation in the hippocampus, and reduced 5-HT(1A) expression in the dorsal raphe. Postnatal treadmill exercise by offspring, but not maternal exercise during pregnancy, enhanced cell proliferation and expression of these proteins.CONCLUSIONS:
Postnatal treadmill exercise ameliorated anxiety-like behaviors in offspring of stressed pregnant rats, and the alleviating effect of exercise on these behaviors is hypothesized to result from enhancement of cell proliferation through 5-HT(1A) activation in offspring rats.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ansiedade
/
Efeitos Tardios da Exposição Pré-Natal
/
Proteínas Tirosina Quinases
/
Bromodesoxiuridina
/
Imuno-Histoquímica
/
Serotonina
/
Western Blotting
/
Fatores de Risco
/
Giro Denteado
/
Fator Neurotrófico Derivado do Encéfalo
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
International Neurourology Journal
Ano de publicação:
2016
Tipo de documento:
Artigo