Effects of mitomycin C on delayed adjustment in experimental strabismus surgery
Korean Journal of Ophthalmology
; : 51-58, 1995.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-123061
Biblioteca responsável:
WPRO
ABSTRACT
In adjustable strabismus surgery, a satisfactory final result would be achieved with delayed adjustment. However, the postoperative adhesions following strabismus surgery make delayed adjustment impossible. We evaluated the efficacy of mitomycin C in reducing the severity of postoperative adhesions following strabismus surgery and in delaying the time adjustment after surgery. Experimental rabbits underwent a hang-back recession procedure in the superior rectus muscle. A topical application of mitomycin C was made between the conjunctiva and the sclera for 5 minutes during the operation. We then studied the possible time of delayed adjustment and estimated the minimal forces required for the adjustment. The topical application of 0.1 mg/ml mitomycin C between the conjunctiva and sclera allowed for a 2-week delayed adjustment after surgery, and 0.2 mg/ml mitomycin C prevented the adhesions between these tissues and the muscle 5 weeks after surgery. These results suggest that topical mitomycin C may enhance the success rate of strabismus surgery with delayed adjustment and reduce postoperative adhesions.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Soluções Oftálmicas
/
Complicações Pós-Operatórias
/
Esclera
/
Aderências Teciduais
/
Estrabismo
/
Administração Tópica
/
Técnicas de Sutura
/
Mitomicina
/
Quimioterapia Adjuvante
/
Túnica Conjuntiva
Limite:
Animais
Idioma:
Inglês
Revista:
Korean Journal of Ophthalmology
Ano de publicação:
1995
Tipo de documento:
Artigo