Hemophagocytic Lymphohistiocytosis Occurring after Induction Chemotherapy in Acute Myelocytic Leukemia / 대한내과학회지
Korean Journal of Medicine
; : 79-83, 2016.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-123564
Biblioteca responsável:
WPRO
ABSTRACT
Hemophagocytic lymphohistiocytosis (HLH), associated with acute myelocytic leukemia (AML), is a very rare disease. We here report a case of HLH occurring after induction chemotherapy for AML. AML-associated HLH can be triggered by AML itself, by chemotherapeutic agents, or by infectious complications. Our patient developed a high-grade fever of unknown cause, bilateral pulmonary infiltrates, and shock after successful treatment of AML with induction chemotherapy, and had high serum ferritin, hypertriglyceridemia, hypofibrinogenemia, hemophagocytic histiocytes in bone marrow, low natural killer cell activity, and elevated soluble interleukin-2 receptor levels. A diagnosis of HLH was made. Dexamethasone, cyclosporine, and etoposide were given and allogeneic hematopoietic stem cell transplantation was performed. Careful suspicion of HLH may be warranted if a patient experiences fever of unknown etiology, high ferritin levels, and liver dysfunction during AML treatment.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Choque
/
Medula Óssea
/
Dexametasona
/
Células Matadoras Naturais
/
Hipertrigliceridemia
/
Leucemia Mieloide Aguda
/
Interleucina-2
/
Ciclosporina
/
Transplante de Células-Tronco Hematopoéticas
/
Doenças Raras
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Ano de publicação:
2016
Tipo de documento:
Artigo