Mechanisms of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance and Strategies to Overcome Resistance in Lung Adenocarcinoma / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 248-256, 2016.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-125744
Biblioteca responsável:
WPRO
ABSTRACT
Somatic mutations that lead to hyperactivation of epidermal growth factor receptor (EGFR) signaling are detected in approximately 50% of lung adenocarcinoma in people from the Far East population and tyrosine kinase inhibitors are now the standard first line treatment for advanced disease. They have led to a doubling of progression-free survival and an increase in overall survival by more than 2 years. However, emergence of resistant clones has become the primary cause for treatment failure, and has created a new challenge in the daily management of patients with EGFR mutations. Identification of mechanisms leading to inhibitor resistance has led to new therapeutic modalities, some of which have now been adapted for patients with unsuccessful tyrosine kinase inhibitor treatment. In this review, we describe mechanisms of tyrosine kinase inhibitor resistance and the available strategies to overcoming resistance.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteínas Tirosina Quinases
/
Resistência a Medicamentos
/
Adenocarcinoma
/
Células Clonais
/
Falha de Tratamento
/
Genes erbB-1
/
Intervalo Livre de Doença
/
Fator de Crescimento Epidérmico
/
Ásia Oriental
/
Receptores ErbB
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Tuberculosis and Respiratory Diseases
Ano de publicação:
2016
Tipo de documento:
Artigo