Association between the G252A Tumor Necrosis Factor-beta Gene Polymorphism and Medication-Overuse Headache
Journal of Clinical Neurology
; : 301-304, 2012.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-12700
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE:
Migraine patients are particularly prone to the complication of medication-overuse headache (MOH). Although it has been shown that A allele carriers for the tumor necrosis factor (TNF)-beta gene G252A polymorphism are at high risk of the development of migraine without aura, the relationship between the TNF-beta gene G252A polymorphism and MOH is unknown. We investigated whether the TNF-beta gene G252A polymorphism is involved in the aggravation of migraine by overuse of medications.METHODS:
Forty-seven migraine patients (6 males and 41 females; age 36.4+/-10.3 years, mean+/-SD) and 22 MOH patients (1 male and 21 females; age 39.6+/-9.9 years) who had migraine were included in this study. The genotype for the TNF-beta gene G252A polymorphism was determined by polymerase-chain-reaction restriction-fragment-length polymorphism analysis.RESULTS:
The distribution of TNF-beta gene G252A genotype frequency differed significantly between migraine and MOH patients (p=0.013). The G/G genotype was carried by 23% of the migraine patients but it was absent in MOH patients.CONCLUSIONS:
G/G genotype carriers appear to be less susceptible to the aggravation of migraine by overuse of medications. The G252A TNF-beta gene polymorphism may be one of the factors contributing to the complications of MOH in patients with migraine.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linfotoxina-alfa
/
Fator de Necrose Tumoral alfa
/
Enxaqueca sem Aura
/
Alelos
/
Genótipo
/
Cefaleia
/
Transtornos de Enxaqueca
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Journal of Clinical Neurology
Ano de publicação:
2012
Tipo de documento:
Artigo