Effects of Sinapic Acid of 4 Vessel Occlusion Model-Induced Ischemia and Cognitive Impairments in the Rat
Clinical Psychopharmacology and Neuroscience
; : 86-90, 2011.
Article
em En
| WPRIM
| ID: wpr-127841
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: Sinapic acid (SA, Sinapine), small naturally occurring hydroxycinnamic acid, has a GABA(A) receptor agonistic property and free radical scavenging activity. We examined potential neuroprotective effects of sinapic acid (SA) using global cerebral ischemia animal model. METHODS: MTT assay was performed to determine cytotoxic effects of SA. To examine the neuroprotective effects of SA, SA was administrated for 14 d before 4-vessel occlusion. Also, to determine whether SA prevents cognitive impairment, Morris water maze was performed. RESULTS: In this study, the efficacy of SA for the prevention of neuronal damage and for the reduction of memory impairment was investigated. CONCLUSION: The results indicate that SA confers significant neuroprotection especially for ischemic hippocampal neurons.
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Base de dados:
WPRIM
Assunto principal:
Isquemia Encefálica
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Receptores de GABA-A
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Fármacos Neuroprotetores
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Aprendizagem em Labirinto
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Ácidos Cumáricos
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Glicosaminoglicanos
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Hipocampo
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Isquemia
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Memória
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Neurônios
Limite:
Animals
Idioma:
En
Revista:
Clinical Psychopharmacology and Neuroscience
Ano de publicação:
2011
Tipo de documento:
Article