The Interplay between Autophagy and Aging
Diabetes & Metabolism Journal
; : 333-339, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-130788
Biblioteca responsável:
WPRO
ABSTRACT
Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various factors due to the gradual failure of cellular maintenance. Recent studies have shown that autophagy reduces the stress responses induced by starvation, reactive oxygen species, and the accumulation of intracellular proteins and organelles through cytoprotection, clearance of damaged mitochondria, and lysosomal degradation. Here, we summarize our current understanding of the relationship between autophagy and the aging process.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Autofagia
/
Inanição
/
Envelhecimento
/
Organelas
/
Proteínas
/
Espécies Reativas de Oxigênio
/
Citoproteção
/
Restrição Calórica
/
Mitocôndrias
Idioma:
Inglês
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2013
Tipo de documento:
Artigo