Induction of Contraception by Intraepididymal Sclerotherapy
The World Journal of Men's Health
; : 83-86, 2014.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-132481
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
The objective of the present study was to evaluate the efficacy of a sclerosing solution for inducing epididymal occlusion in male rats. MATERIALS ANDMETHODS:
Male Sprague-Dawley rats were divided into two groups an injection group (n=20) and control group (n=20). Before injecting the sclerosing agent, seminal vesiculectomy and sperm identification using electrostimulation were performed in all of the rats. In the injection group, 0.2 mL of 0.1% sodium tetradecyl sulfate solution was injected into the epididymis. In the sham group, only the identification of the epididymis was performed. At 4 and 12 weeks after the injection, semen was collected by electrostimulation and evaluated to assess the contraceptive effect. Epididymis was evaluated by hematoxylin and eosin (H&E) staining.RESULTS:
After 4 and 12 weeks, semen collection was performed in the two groups. Sperms were not observed in the injection group, while there was no change in the sperms in the sham group. H&E staining showed the obstruction of epididymal tubules and an accumulation of inflammatory cells in the injection group.CONCLUSIONS:
This study showed that the sclerosing agent induced sterilization in male rats. This result suggests that the injection method can replace vasectomy as a contraceptive method. However, a further study of large animals and a clinical study are needed. Further, the long-term effectiveness of this method needs to be studied.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sêmen
/
Tetradecilsulfato de Sódio
/
Espermatozoides
/
Vasectomia
/
Escleroterapia
/
Esterilização
/
Ratos Sprague-Dawley
/
Amarelo de Eosina-(YS)
/
Anticoncepção
/
Anticoncepcionais
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The World Journal of Men's Health
Ano de publicação:
2014
Tipo de documento:
Artigo