-1438A/G Polymorphism of the 5-HT2A Receptor Gene in Korean and Han Chinese Patients with Schizophrenia / 신경정신의학
Journal of Korean Neuropsychiatric Association
; : 25-31, 2005.
Article
em Ko
| WPRIM
| ID: wpr-139125
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES:
The purpose of the present study was to investigate the association between -1438A/G polymorphism of 5-HT2A receptor gene and schizophrenia in Korean and Han Chinese population.METHODS:
A sample of 184 Korean patients with schizophrenia and 96 Korean healthy normal controls and 96 Han Chinese patients with schizophrenia and 96 Han-Chinese healthy normal controls were genotyped for a single nucleotide polymorphism with in 5-HT2A receptor gene (promoter region, A-1438G) by Msp I Restriction Fragment Length Polymorphism (RFLP).RESULTS:
There was no difference in allelic frequencies and genotype frequencies of -1438A/G polymorphism between Korean schizophrenics and controls (p=0.13) and Han Chinese schizophrenics and controls (p=0.40). Also, -1438A/G polymorphism did not show ethnical difference between Korean and Han Chinese controls. The Scale for the Assessment of Negative Symptoms (SANS) scores showed no significant differences between genotypes of -1438A/G polymorphism in both of Korean and Han Chinese schizophrenics.CONCLUSION:
These results suggest that -1438A/G polymorphism of the 5-HT2A receptor gene is not causally related to the development of schizophrenia in Korean and Han Chinese population, and there no ethnic difference between Korean and Han Chinese population.Palavras-chave
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Esquizofrenia
/
Polimorfismo de Fragmento de Restrição
/
Polimorfismo de Nucleotídeo Único
/
Receptor 5-HT2A de Serotonina
/
Povo Asiático
/
Genótipo
Limite:
Humans
Idioma:
Ko
Revista:
Journal of Korean Neuropsychiatric Association
Ano de publicação:
2005
Tipo de documento:
Article