Phenotypic Differences of Gastric Cancer according to the Helicobacter pylori Infection in Korean Patients
Journal of Gastric Cancer
; : 168-174, 2010.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-139729
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
Infection with Helicobacter pylori is an important risk factor for gastric cancer in humans. We compared the clinicopathologic features of gastric cancer patients based on H. pylori infection. MATERIALS ANDMETHODS:
We prospectively studied 155 patients who had gastric cancer and underwent gastrectomies in 1 hospital in Korea. We examined H. pylori infections using the rapid urease test (RUT) with gastrectomy specimens and collected clinical and pathologic data.RESULTS:
The number of H. pylori infections based on the RUT was 137 (88%). The H. pylori-negative group was significantly associated with AGC and tumor histology. H. pylori infection was significantly correlated with type I/IIa in EGC and type III/IV/V in AGC. AGC was significantly correlated with larger tumor size, lymphatic invasion, perineural invasion, and H. pylori infection based on univariate and multivariate analyses.CONCLUSIONS:
We report the prevalence of H. pylori based on the RUT in gastric cancer patients. H. pylori infection influences the tumor histology, progression, and growth type of gastric cancer.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Neoplasias Gástricas
/
Urease
/
Prevalência
/
Estudos Prospectivos
/
Fatores de Risco
/
Helicobacter pylori
/
Helicobacter
/
Gastrectomia
/
Coreia (Geográfico)
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Gastric Cancer
Ano de publicação:
2010
Tipo de documento:
Artigo