Relationship between Helicobacter pylori infection and iron-deficiency anemia in infants and children / 소아과
Korean Journal of Pediatrics
; : 544-548, 2009.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-143346
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
To elucidate a potential association between Helicobacter pylori (HP) infection and iron-deficiency anemia (IDA) in infants and children in terms of the other factors related to iron utilization and storage although the association of ferritin was previously studied.METHODS:
We evaluated 135 infants (aged 6-24 months) admitted at Gyeongsang National University Hospital from 2000 to 2006. Western blot assays using the HP CagA antigen (120 kD) were conducted to identify infections. The concentrations of six parameters were measured hemoglobin (Hb), serum ferritin, soluble serum transferrin receptors, interleukin-6, prohepcidin, and C-reactive protein. In addition, the infants were classified into IDA, anemia from inflammation (AI), unclassified anemia (UCA), and normal groups on the basis of Hb and ferritin concentrations.RESULTS:
In the IDA group (n=20), seven infants were infected with HP, with the other infants showing no evidence of infection. The mean Hb levels in the IDA group were significantly lower in HP-infected infants than those uninfected (7.1 vs. 8.2 g/dL, respectively); the mean ferritin levels were also significantly lower in the infected infants (3.2 vs. 6.8 microgram/L). The other four parameters did not differ significantly among the IDA infants. No correlations were found between the six parameters and HP infection status in the other groups.CONCLUSION:
There were no significant differences in the HP infection rates among the study groups. However, in the IDA group, the HP-infected infants had significantly lower serum ferritin and Hb levels than the HP-negative infants (P<0.05).
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Precursores de Proteínas
/
Receptores da Transferrina
/
Proteína C-Reativa
/
Hemoglobinas
/
Western Blotting
/
Helicobacter pylori
/
Interleucina-6
/
Helicobacter
/
Anemia Ferropriva
/
Peptídeos Catiônicos Antimicrobianos
Tipo de estudo:
Estudo prognóstico
Limite:
Criança
/
Humanos
/
Lactente
Idioma:
Coreano
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2009
Tipo de documento:
Artigo