Clinical Characteristics and Prognostic Factors of Papillary Microcarcinoma: Results from Retrospective Analysis of 176 Patients / 대한내분비외과학회지
Korean Journal of Endocrine Surgery
; : 79-84, 2009.
Article
em Ko
| WPRIM
| ID: wpr-145359
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: The clinical importance and characteristics of papillary thyroid microcarcinoma (PTC) are still under debate, and the criteria for appropriate treatment have yet to be established. In this study, we attempted to examine the appropriate extent of surgery and the desirability of prophylactic lymph node (LN) dissection through identification of factors influencing LN metastasis and capsular invasions. METHODS: We reviewed the medical records of 176 consecutive biopsy-proven PTC patients. The clinical and pathological prognostic factors including LN metastasis and capsular invasion were analyzed. Chi-square test and independent sample T-test were used for statistical analysis. RESULTS: The median age of patients was 47-years-of-age (range 23~80 years). Among 108 patients who underwent central LN dissection, 38 (35.8%) patients showed LN metastasis. Univariate analysis revealed that male patients showed significantly more LN metastasis than female patients and lymphovascular invasion significantly affected LN metastasis. Twenty-eight (14.8%) patients showed capsular invasion. Tumor size, especially tumors ≥5 mm in diameter, and tumor multiplicity were significantly associated with capsular Invasion. Lymphatic or venous invasion also affected the occurrence of capsular invasion. CONCLUSION: Patients who are male, have a tumor larger than 5 mm in diameter, or multiple tumors are more likely to develop LN metastasis or capsular invasions. These factors could help us to decide the extent of thyroidectomy and to select patients who need prophylactic LN dissection.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Glândula Tireoide
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Tireoidectomia
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Prontuários Médicos
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Estudos Retrospectivos
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Linfonodos
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Metástase Neoplásica
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Female
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Humans
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Male
Idioma:
Ko
Revista:
Korean Journal of Endocrine Surgery
Ano de publicação:
2009
Tipo de documento:
Article