A Case of Interstitial Pneumonitis Caused by Leflunomide / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 83-88, 2005.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-145380
Biblioteca responsável:
WPRO
ABSTRACT
Leflunomide is a new disease modifying anti rheumatic drug (DMARD) for the treatment of active rheumatoid arthritis. Its mechanism of action differs from other DMARDs in that it inhibits the de novo pyrimidine synthesis by inhibiting dihydroorotate dehydrogenase and therefore prevents the proliferation of activated lymphocytes. As it has been prescribed worldwide, there is a great deal of much concerns regarding its potential adverse effects. Because leflunomide has an active metabolite with a long elimination half life of approximately 2 weeks, serious adverse reactions may occur even after the leflunomide treatment has been stopped. The profile of serious reactions includes liver dysfunction, hematological disorders, severe skin reactions and respiratory dysfunction. Respiratory dysfunctions with leflunomide therapy are very rare and its incidence is lower than that of methotrexate therapy. However, there are reports in Japan showing that 5 patients died of interstitial pneumonitis and another 11 patients developed serious lung complications associated with leflunomide. This suggests the possibility of fatal respiratory toxicity of leflunomide. There are no reports of interstitial pneumonitis associated with leflunomide in Korea. We report a case of a 62-year old woman who developed interstitial pneumonitis, which might have been induced by leflunomide during the treatment of rheumatoid arthritis.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Problema de saúde:
Pneumonía
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxirredutases
/
Artrite Reumatoide
/
Pele
/
Linfócitos
/
Metotrexato
/
Incidência
/
Doenças Pulmonares Intersticiais
/
Antirreumáticos
/
Meia-Vida
/
Japão
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Tuberculosis and Respiratory Diseases
Ano de publicação:
2005
Tipo de documento:
Artigo