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Increased expression of pAKT is associated with radiation resistance in cervical cancer / 부인종양
Article em Ko | WPRIM | ID: wpr-147180
Biblioteca responsável: WPRO
ABSTRACT
OBJECTIVE: The aim of this study was to investigate the association of phosphorylated AKT (pAKT) expression and radiation resistance in cervical cancer. METHODS: A retrospective review was made of the records of 25 women who received primary radiation therapy due to locally advanced cervical cancer (LACC) with FIGO stage IIB-IVA. Nine patients regarded as radiation resistant developed local recurrences with a median progression free interval of 10 months. Sixteen patients did not show local recurrences, and were regarded as a radiation sensitive group. Using pretreatment paraffin-embedded tissues, we evaluated pAKT expression by immunohistochemistry. RESULTS: A significant association was found between the level of pAKT expression and local recurrence. Immunohistochemical staining for pAKT was significantly more frequent in the radiation resistant than in the radiation sensitive group (p=0.007). The mean progression free survival (PFS) was 84 months for patients with pAKT negative staining (17 cases) and 44 months for patients with pAKT positive expression (8 cases)(p=0.015). CONCLUSION: These results suggest that signaling from PI3K/pAKT can lead to radiation resistance in LACC.
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Texto completo: 1 Base de dados: WPRIM Assunto principal: Recidiva / Imuno-Histoquímica / Neoplasias do Colo do Útero / Estudos Retrospectivos / Coloração Negativa / Intervalo Livre de Doença Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: Ko Revista: Korean Journal of Gynecologic Oncology Ano de publicação: 2006 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Assunto principal: Recidiva / Imuno-Histoquímica / Neoplasias do Colo do Útero / Estudos Retrospectivos / Coloração Negativa / Intervalo Livre de Doença Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: Ko Revista: Korean Journal of Gynecologic Oncology Ano de publicação: 2006 Tipo de documento: Article