A Case of Treatment with Etanercept in Rheumatoid Arthritis Patient on Hemodialysis / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
; : 317-321, 2008.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-147964
Biblioteca responsável:
WPRO
ABSTRACT
Disease-modifying antirheumatic drugs (DMARDs) have been used for rheumatoid arthritis (RA) with the aim of controlling synovitis and reducing radiologic progression. Although methotrexate (MTX) is one of the most effective DMARDs, it may cause severe adverse effects. Especially, hematologic toxicity including leukopenia, thrombocytopenia, and fatal pancytopenia is reported in patients with impaired renal function, since renal excretion constitutes the major route of MTX elimination. Tumor necrosis factor-alpha (TNF alpha) inhibitors are well-established biologic agents for the treatment of RA and their clinical efficacy and safety are already demonstrated. But there were few reports on the efficacy and safety in dialysis patients. We described a case of hemodialysis patient with refractory RA that was successfully treated with etanercept, and discussed with literature review.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fator de Necrose Tumoral alfa
Idioma:
Coreano
Revista:
The Journal of the Korean Rheumatism Association
Ano de publicação:
2008
Tipo de documento:
Artigo