Reflux Hypersensitivity: A New Functional Esophageal Disorder
Journal of Neurogastroenterology and Motility
; : 495-503, 2017.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-14800
Biblioteca responsável:
WPRO
ABSTRACT
Reflux hypersensitivity, recently introduced by Rome IV as a new functional esophageal disorder, is currently considered as the presence of typical heartburn symptoms in patients with normal upper endoscopy and esophageal biopsies, normal esophageal pH test and with evidence of a close correlation between patients' heartburn and reflux events. Reflux hypersensitivity is very common and together with functional heartburn accounts for more than 90% of the heartburn patients who failed treatment with proton pump inhibitor twice daily. In addition, reflux hypersensitivity affects primarily young to middle aged women, commonly overlaps with another functional gastrointestinal disorders, and is often associated with some type of psychological comorbidity. Diagnosis is made by using endoscopy with esophageal biopsies, pH-impedance, and high-resolution esophageal manometry. Reflux hypersensitivity is primarily treated with esophageal neuromodulators, such as tricyclic anti-depressants and selective serotonin reuptake inhibitors among others. Surgical anti-reflux management may also play an important role in the treatment of reflux hypersensitivity.
Texto completo:
Disponível
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Diarreia
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Biópsia
/
Dor no Peito
/
Comorbidade
/
Inibidores Seletivos de Recaptação de Serotonina
/
Bombas de Próton
/
Neurotransmissores
/
Diagnóstico
/
Endoscopia
/
Esôfago
/
Gastroenteropatias
Tipo de estudo:
Estudo diagnóstico
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Journal of Neurogastroenterology and Motility
Ano de publicação:
2017
Tipo de documento:
Artigo