Adenosine 5'-triphosphate induced NF-kappa B and intracellular calcium mobilization in cervical cancer cells / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
; : 2903-2909, 2005.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-150617
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To know the effect of adenosine 5'-triphosphate (ATP) on intracellular calcium level and cell proliferation in cervical cancer cells.METHODS:
Studydesign:
Four different human cervical cancer cell lines (Caski, C33A, HeLaS3 and SiHa) were used in this study. The change of intracellular calcium level, cell proliferation and the activity of proliferation- and calcium-related transcription factors by extracellular ATP were examined in these cell lines.RESULTS:
Extracellular ATP induced calcium mobilization, cell proliferation and the activation of NF-kappa B in all cell lines used.CONCLUSION:
These results suggest that calcium mobilization and NF-kappa B dependent signaling pathway play an important role in the cell proliferation by ATP in cervical cancer.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Transcrição
/
Adenosina
/
Linhagem Celular
/
Trifosfato de Adenosina
/
Neoplasias do Colo do Útero
/
Cálcio
/
NF-kappa B
/
Proliferação de Células
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2005
Tipo de documento:
Artigo