Biflorin Ameliorates Memory Impairments Induced by Cholinergic Blockade in Mice
Biomolecules & Therapeutics
; : 249-258, 2017.
Article
em En
| WPRIM
| ID: wpr-151382
Biblioteca responsável:
WPRO
ABSTRACT
To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time in the passive avoidance task, ameliorated alternation behavior in the Y-maze, and increased exploration time in the Morris water maze task, indicating the improvement of cognitive behaviors against cholinergic dysfunction. The biflorin-induced reverse of latency in the scopolamine-treated group was attenuated by MK-801, an NMDA receptor antagonist. Biflorin also enhanced cognitive function in a naïve mouse model. To understand the mechanism of biflorin for memory amelioration, we performed Western blot. Biflorin increased the activation of protein kinase C-ζ and its downstream signaling molecules in the hippocampus. These results suggest that biflorin ameliorates drug-induced memory impairment by modulation of protein kinase C-ζ signaling in mice, implying that biflorin could function as a possible therapeutic agent for the treatment of cognitive problems.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Proteínas Quinases
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Água
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Western Blotting
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Maleato de Dizocilpina
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N-Metilaspartato
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Cognição
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Transtornos Cognitivos
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Syzygium
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Hipocampo
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Memória
Limite:
Animals
Idioma:
En
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2017
Tipo de documento:
Article