A Case of Acute Promyelocytic Leukemia with a De novo t(11;19) Chromosomal Translocation / 대한내과학회지
Korean Journal of Medicine
; : S268-S272, 2011.
Article
em Ko
| WPRIM
| ID: wpr-152515
Biblioteca responsável:
WPRO
ABSTRACT
Acute promyelocytic leukemia (APL), which is usually defined by the morphological features of the leukemic cells, is characterized by the t(15;17) (q22;q21) chromosomal translocation and disseminated intravascular coagulation. This specific translocation results in a new fusion transcript between the promyelocytic leukemia (PML) gene and the retinoic acid receptor-alpha (RARalpha) gene. Although the presence of this fusion gene can predict a favorable clinical response to all-trans-retinoic-acid (ATRA) treatment, APL with chromosomal translocations other than t(15;17) (q22;q21) is extremely rare and is associated with a poor prognosis. We experienced a case of APL with de novo t(11;19).
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Prognóstico
/
Translocação Genética
/
Tretinoína
/
Leucemia Promielocítica Aguda
/
Leucemia
/
Coagulação Intravascular Disseminada
/
Patologia Molecular
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
Ko
Revista:
Korean Journal of Medicine
Ano de publicação:
2011
Tipo de documento:
Article