MicroRNA-200c as a Prognostic Biomarker for Pancreatic Cancer / 대한소화기학회지
The Korean Journal of Gastroenterology
; : 215-220, 2015.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-153829
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS:
MicroRNA (miRNA) regulates messenger RNA stability and translation. In cancer biology, miRNA affects the growth and metastasis of cancer cells by controlling epithelial-mesenchymal transition (EMT). MiR-200 family (200a/200b/200c/141) and miR-205 are associated with the regulation of EMT. We investigated the prognostic role of EMT-related miRNAs in pancreatic cancer.METHODS:
We analyzed miR-200 family and miR-205 expression in tissue samples of 84 patients who underwent radical resection for pancreatic cancer.RESULTS:
Patients were followed from the date of diagnosis until death or censoring. The mean overall survival was 25.0+/-2.0 months (2-140 months). The R0 resection rate was obtained in 84.5% (n=71) of patients. The relative expressions of miR-200a/200b/200c/141 and miR-205 were 266.9+/-57.3/18.5+/-2.2/0.7+/-0.1/27.2+/-6.6 folds and 0.1+/-0.1 compared with human pancreatic ductal epithelial cells, respectively. Overall survival was longer in the low miR-200c expression group than in the high expression group (35 vs. 19 months, p=0.013). Multivariate analysis confirmed that patients with low miR-200c expression survived longer than the high expression group (hazard ratio, 1.771; 95% CI, 1.081-2.900; p=0.023). There was a trend toward longer disease-free survival in low miR-200c group without statistical significance (p=0.061).CONCLUSIONS:
The expression of miR-200c may be an important prognosis factor in pancreatic cancer, and it could be a novel therapeutic target of pancreatic cancer.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doenças do Sistema Endócrino
/
Neoplasia Pancreática
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Pancreáticas
/
Prognóstico
/
Biomarcadores Tumorais
/
Modelos de Riscos Proporcionais
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Análise Multivariada
/
Taxa de Sobrevida
/
Intervalo Livre de Doença
/
MicroRNAs
/
Reação em Cadeia da Polimerase em Tempo Real
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Idoso, 80 anos ou mais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2015
Tipo de documento:
Artigo