A case of PTU(propylthiouracil)-induced agranulocytosis in Graves' disease: additional cases of antithyroid drug-induced agranulocytosis in Yonsei University Hospital last 10 years / 대한내과학회지
Korean Journal of Medicine
; : 398-403, 2001.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-153927
Biblioteca responsável:
WPRO
ABSTRACT
Since introduce of antithyroid drugs (ATDs) in 1941, they have been widely used for treatment of Graves' disease and other hyperthyroid disorders. However, agranulocytosis, the most serious adverse effect of ATD treatment, has been occasionally reported. Agranulocytosis should be diagnosed and be treated promptly due to possible fatality.We have experienced a 17 year-old girl with PTU (propylthiouracil)-induced agranulocytosis. Initial graulocyte count was 400/mm2, and presenting symtoms were fever and sore throat. She has recovered from agranulocytosis without complications after use of G-CSF (granulocyte-colony stimulating factor). We reviewed and analyzed additional 7 cases of ATD-induced agranulocytosis in Yonsei University Hospital (From 1988 to 1998). We found that ATD-induced agranulocytosis, of which incidence is known to be ranged from 0.1 to 1 per cent, does not seem to have a distinct correlation with sex, age, dosage, and the kind of ATD. Event of agranulocytosis has a tendency to occur within 3 months, and in a few case it has been occasionally detected in asymptomatic patients, routine monitoring of the white blood cell count within 3 months after the start of ATD medication can be helpful in predicting and in detecting agranulocytosis. The treatment of ATD-induced agranulocytosis has been mainly composed of conservative care, but according to introduction and popular application of G-CSF, the use of G-CSF seems to be a promise of a reduction in morbidity and mortality.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doenças do Sistema Endócrino
/
Outras Doenças Respiratórias
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antitireóideos
/
Faringite
/
Doença de Graves
/
Incidência
/
Mortalidade
/
Fator Estimulador de Colônias de Granulócitos
/
Agranulocitose
/
Febre
/
Contagem de Leucócitos
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Adolescente
/
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Ano de publicação:
2001
Tipo de documento:
Artigo