Two Cases of Pure Red Cell Aplasia Due to Anti-erythropoietin Antibodies / 대한신장학회잡지
Korean Journal of Nephrology
; : 809-814, 2004.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-154474
Biblioteca responsável:
WPRO
ABSTRACT
We reported upon two Korean patients who developed pure red cell aplasia (PRCA) due to anti- erythropoietin (EPO) antibodies. The first patient became refractory to EPO treatment after a good response for an initial 26 months. Anti-EPO antibodies were detected by ELISA and by radioimmunoprecipitation, and these were found to inhibit the formation of erythroid colonies by in-vitro bioassay. In the second patient, the anemia became aggravated, and wheals appeared at the EPO injection site 3 months after the initiation of subcutaneous EPO treatment. Anti-EPO antibodies were detected by ELISA, and he showed partial response to the second course of corticosteroid treatment. Our cases showed that PRCA due to anti-EPO antibodies becomes an important issue in Asian as well as Caucasians.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Bioensaio
/
Ensaio de Imunoadsorção Enzimática
/
Eritropoetina
/
Aplasia Pura de Série Vermelha
/
Povo Asiático
/
Anemia
/
Anticorpos
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Ano de publicação:
2004
Tipo de documento:
Artigo