Lung Cancer Risk and Residential Exposure to Air Pollution: A Korean Population-Based Case-Control Study
Yonsei Medical Journal
; : 1111-1118, 2017.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-15483
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
To investigate the association between long-term exposure to ambient air pollution and lung cancer incidence in Koreans. MATERIALS ANDMETHODS:
This was a population-based case-control study covering 908 lung cancer patients and 908 controls selected from a random sample of people within each Korean province and matched according to age, sex, and smoking status. We developed land-use regression models to estimate annual residential exposure to particulate matter (PM₁₀) and nitrogen dioxide (NO₂) over a 20-year exposure period. Logistic regression was used to estimate odds ratios (ORs) and their corresponding 95% confidence intervals (CI).RESULTS:
Increases in lung cancer incidence (expressed as adjusted OR) were 1.09 (95% CI 0.96−1.23) with a ten-unit increase in PM₁₀ (µg/m³) and 1.10 (95% CI 1.00−1.22) with a ten-unit increase in NO₂ (ppb). Tendencies for stronger associations between air pollution and lung cancer incidence were noted among never smokers, among those with low fruit consumption, and among those with a higher education level. Air pollution was more strongly associated with squamous cell and small cell carcinomas than with adenocarcinoma of the lung.CONCLUSION:
This study provides evidence that PM₁₀ and NO₂ contribute to lung cancer incidence in Korea.
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
/
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fumaça
/
Adenocarcinoma
/
Fumar
/
Estudos de Casos e Controles
/
Modelos Logísticos
/
Razão de Chances
/
Incidência
/
Carcinoma de Células Pequenas
/
Poluição do Ar
/
Educação
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2017
Tipo de documento:
Artigo