PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis
Gut and Liver
; : 456-463, 2016.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-155136
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS:
The recognition of a correlation between patatin-like phospholipase domain containing-protein 3 (PNPLA3) rs738409 (C>G) and the severity of liver steatosis or fibrosis in chronic hepatitis C (CHC) has not reached a consensus. This meta-analysis sought to investigate with accuracy the association between the PNPLA3 rs738409 (C>G) polymorphism and liver steatosis and advanced fibrosis in CHC patients.METHODS:
We performed a comprehensive literature search from the PubMed, Embase, Web of Science, and Google Scholar databases up to December 31, 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Statistical analyses were performed using Stata 12.0 software.RESULTS:
The meta-analysis revealed the severity of liver fibrosis was significantly higher in CHC patients with PNPLA3 rs738409 GG in Caucasians (versus CC+CG OR, 2.29; 95% CI, 1.57 to 3.35; pG) was associated with the risk of both advanced liver fibrosis and steatosis in patients with CHC, especially among Caucasian populations.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfolipases
/
Fibrose
/
Razão de Chances
/
Viés de Publicação
/
Hepatite C Crônica
/
Consenso
/
Povo Asiático
/
Fígado Gorduroso
/
Hepatite Crônica
/
Cirrose Hepática
Tipo de estudo:
Estudo de etiologia
/
Guia de prática clínica
/
Revisão sistemática
Limite:
Humanos
Idioma:
Inglês
Revista:
Gut and Liver
Ano de publicação:
2016
Tipo de documento:
Artigo