Increased Estimated 10-Year Risk for Cardiovascular Disease Assessed Using the Pooled Cohort Equation in Non-Diabetic Subjects According to Increasing HbA1c Levels
Journal of Lipid and Atherosclerosis
; : 123-130, 2015.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-156416
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
In 2013, a new risk calculator known as the Pooled Cohort Equation (PCE) was introduced with the new cholesterol guideline. We aimed to calculate the 10-year atherosclerotic cardiovascular disease (ASCVD) risk using PCE in non-diabetic Korean subjects with glycated hemoglobin (HbA1c) lower than 6.5%.METHODS:
A total of 17,519 participants were evaluated in a health screening program. The 10-year ASCVD risk was calculated using the PCE. Subjects with underlying diabetes or HbA1c > or =6.5% were excluded. Subjects were divided into four groups according to fasting blood glucose (FBG) and HbA1c levels FBG or =120 mg/dL; HbA1c or =5.8%.RESULTS:
The mean 10-year ASCVD risk significantly increased as FBG increased from 120 mg/dL in the four divided groups (2.6%, 3.3%, 3.8%, 4.1%; p5.8% (2.4%, 2.7%, 3.0%, 3.6%; p or =10% significantly increased from group I to IV according to FBG and HbA1c levels after adjusting for age, body mass index and fasting insulin level (1.187, 1.753, and 2.390 vs. 1.0 in the lowest FBG group; 1.626, 1.574, and 1.645 vs. 1.0 in the lowest HbA1c group).CONCLUSION:
The 10-year ASCVD risk calculated using the PCE significantly increased as the FBG and HbA1c increased even in Korean subjects without underlying diabetes.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estado Pré-Diabético
/
Glicemia
/
Hemoglobinas Glicadas
/
Doenças Cardiovasculares
/
Índice de Massa Corporal
/
Razão de Chances
/
Programas de Rastreamento
/
Colesterol
/
Estudos de Coortes
/
Jejum
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
/
Estudo de rastreamento
Aspecto:
Preferência do paciente
Idioma:
Inglês
Revista:
Journal of Lipid and Atherosclerosis
Ano de publicação:
2015
Tipo de documento:
Artigo