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Economic and Clinical Benefits of Galantamine in the Treatment of Mild to Moderate Alzheimer's Disease in a Korean Population: A 52-Week Prospective Study
Article em En | WPRIM | ID: wpr-157452
Biblioteca responsável: WPRO
ABSTRACT
To evaluate the impact of galantamine treatment on the function, caregiver time, and resource used in the treatment of patients with mild to moderate Alzheimer's disease (AD), costs and outcomes were evaluated during a 52-week prospective, randomized, double-blind, community-controlled trial of galantamine. Patients received either galantamine treatment (n=72) or no treatment (n=66). The analysis was performed from a societal perspective. Galantamine treatment reduced time spent caring for the patients and maintained improved functional capacity, whereas, when no treatments were given, a great increase in caregiver time and progressive functional deteriorations were observed. Saved caregiver time was equivalent to 113 working days per year. After 52 weeks, mean total annual costs per patient were 14,735,000 Korea Won (KRW) (USD 12,315) for patients with galantamine treatment and 25,325,000 KRW (USD 21,166) for patients without treatment. Adjusted annual cost saving of galantamine treatment was 6,428,000 KRW (USD 5,372) when compared to no treatment (p=0.0089). Galantamine had a beneficial effect not only to slow functional decline in patients with mild to moderate AD, but also to save a substantial amount of costs, closely related to reduction in caregiver burden and decrease in caregiver time.
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Texto completo: 1 Base de dados: WPRIM Assunto principal: Método Duplo-Cego / Inibidores da Colinesterase / Estudos Prospectivos / Custos de Cuidados de Saúde / Efeitos Psicossociais da Doença / Doença de Alzheimer / Galantamina Tipo de estudo: Clinical_trials / Health_economic_evaluation / Observational_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Journal of Korean Medical Science Ano de publicação: 2008 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Assunto principal: Método Duplo-Cego / Inibidores da Colinesterase / Estudos Prospectivos / Custos de Cuidados de Saúde / Efeitos Psicossociais da Doença / Doença de Alzheimer / Galantamina Tipo de estudo: Clinical_trials / Health_economic_evaluation / Observational_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Journal of Korean Medical Science Ano de publicação: 2008 Tipo de documento: Article