A Moderate Case of Hemolytic Disease in a Newborn Caused by Anti-M Antibody / 대한임상병리학회지
Korean Journal of Clinical Pathology
; : 72-75, 2001.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-161360
Biblioteca responsável:
WPRO
ABSTRACT
Anti-M antibodies are usually assumed to be naturally occurring and to consist of immunoglobulin M reacting at 4degrees C. They are not usually considered to be clinically significant, however, many of them have an immunoglobulin G component reacting at 37degrees C and can be correlated with hemolytic disease of the newborn (HDN). We report a moderate case of HDN by anti-M. A 2-days old baby born from a mother with preeclampsia as a second pregnancy was admitted due to anemia, hyperbilirubinemia and hypoxic encephalopathy. The blood type of mother was AB, ccDEE, NN, and the blood type of baby was A, D+, and MN. Antibody screening and identification identified anti-M antibody which was strong reactive at 37degrees C albumin and antiglobulin phase in both baby's and her mother's serum. The direct antiglobulin test of baby's red blood cells was negative. The infant was transfused with group O red cells which have negative to trace reaction with her mother's serum in antiglobulin phase. Two days later, the hemoglobin level elevated from 6.7 g/dL to 15.9 g/dL falled to below 11 g/dL quite soon. After all, newborn died of cardiac arrest due to her basic disease at age of 49 days; metabolic acidosis and hypernatremia.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pré-Eclâmpsia
/
Acidose
/
Imunoglobulina G
/
Imunoglobulina M
/
Teste de Coombs
/
Hipóxia Encefálica
/
Programas de Rastreamento
/
Eritrócitos
/
Parada Cardíaca
/
Hiperbilirrubinemia
Tipo de estudo:
Estudo de rastreamento
Limite:
Humanos
/
Lactente
/
Recém-Nascido
/
Gravidez
Idioma:
Coreano
Revista:
Korean Journal of Clinical Pathology
Ano de publicação:
2001
Tipo de documento:
Artigo