Comparison of Erythrocyte Traits Among European, Japanese and Korean
Genomics & Informatics
; : 159-163, 2010.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-162265
Biblioteca responsável:
WPRO
ABSTRACT
Erythrocyte traits are heritable and indirect indicators of blood diseases caused by erythrocyte, but their genetic factors are largely unknown. So we performed genome-wide association study in 8,842 Korean individuals to identify genetic factors influencing erythrocyte traits. We identified 40 associations for three erythrocyte traits at genome-wide significance levels (p<1x10-6). We compared these associated loci with those reported in genome-wide association studies of European and Japanese. Our findings include previously identified loci (HBS1L-MYB, TMPRSS6, USP49 and CCND3) in other studies and novel associations (MRDS1/OFCC1, CSDE1, NRAS and 8 other loci). For example, SNP rs4895440 of HBS1L-MYB intergenic region on chromosome 6q23.3 is one of the most associations influencing erythrocyte traits (p=8.33x10-27).
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Hemoglobinas
/
DNA Intergênico
/
Povo Asiático
/
Eritrócitos
/
Estudo de Associação Genômica Ampla
/
Hematócrito
/
Doenças Hematológicas
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Genomics & Informatics
Ano de publicação:
2010
Tipo de documento:
Artigo